Fig. 4: ecDNA structure heterogeneity.
From: Modern biology of extrachromosomal DNA: A decade-long voyage of discovery
a Within a single cell, different species of ecDNAs co-exist and can undergo circular recombination, generating various subspecies of ecDNAs. ecDNA–virus hybrid was also observed, possibly due to recombination between ecDNA and virus episome. b ecDNA can reintegrate into chromosomes, leading to chromosomal rearrangement.
