Fig. 7: ecDNA-centered cancer biology and therapeutic vulnerabilities. | Cell Research

Fig. 7: ecDNA-centered cancer biology and therapeutic vulnerabilities.

From: Modern biology of extrachromosomal DNA: A decade-long voyage of discovery

Fig. 7

ecDNA drives cancer transformation and progression, highlighting ecDNA as a therapeutic target. Opportunities to target ecDNA lie in its formation and maintenance mechanisms. In addition, understanding how cell-intrinsic processes and immune surveillance sense ecDNAs, and how ecDNA tumors evade these checkpoints, could further unlock therapeutic potential. Finally, ecDNA detection and diagnostic tools are required for ecDNA-directed clinical practices.

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