Fig. 1: Metabolic process and inflammatory signaling are orchestrated during inflammation via SLG-induced lysine d-lactylation. | Cell Research

Fig. 1: Metabolic process and inflammatory signaling are orchestrated during inflammation via SLG-induced lysine d-lactylation.

From: Metabolite is a part of immune-regulating circuit

Fig. 1

Inflammatory signaling triggered TTP-dependent mRNA decay of GLO2, resulting in intracellular accumulation of SLG. By the law of mass action, accumulated SLG spontaneously induces the d-lactylation of proteins that are involved in inflammatory responses, which in turn feeds back to attenuate inflammatory response, thereby maintaining a proper immune activation. TTP tristetraprolin, MGO methylglyoxal, SLG S-d-lactoylglutathione, IFIT3 interferon induced protein with tetratricopeptide repeats 3, ISG15 interferon-induced 15 kDa protein, MAPK1 mitogen-activated protein kinase 1, STAT1 signal transducer and activator of transcription 1.

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