Fig. 3: The specificity of TCR is regulated by CD8 cooperating with dynamic force.
From: TCR catch bonds nonlinearly control CD8 cooperation to shape T cell specificity
a–c Left, The analysis of TCR bond lifetime ratio (R4 to L4) in three force regimes: low (2–5 pN) (a), medium (9–12 pN) (b), and high (16–19 pN) (c) regimes, in the absence or presence of CD8. Right, the relationship between CD8 enhancement power and TCR–pMHC bi-molecular lifetimes in the low (a), medium (b), or high (c) force regimes. All data points are presented as mean ± SEM and summarized in Supplementary information Tables S6, S8. The statistical analyses for the left panels of a–c were conducted using unpaired student's t-tests, and the right panels of a–c were performed using the Mann–Whitney test, with 2C-TCR–L4-MHC as a control. Statistical significance was indicated as follows: ns not significant, *P < 0.05, ***P < 0.001, ****P < 0.0001.
