Fig. 7: The 2D affinities and force-dependent bond lifetimes of TCR–pMHC bi-molecular interactions shape TCR antigen recognition.
From: TCR catch bonds nonlinearly control CD8 cooperation to shape T cell specificity
a Schematic diagram of the force-dependent kinetic proofreading model of TCR triggering in the presence of CD8. b, c Mapping of TCR–pMHC 2D affinities and bond lifetimes in the medium force regime onto kinetics-function maps, in the absence (b) or presence of CD8 (c) Data presented include both our experimental results and previously published data. The bond lifetime data for NP366-H-2Db-specific canonical B13.C1-TCR and B17.C1-TCR were from a previous study.56 All other data were from our own experiments.
