Fig. 4: Interactions between NTSR1 and βArr1 in the loop engagement configuration. | Cell Research

Fig. 4: Interactions between NTSR1 and βArr1 in the loop engagement configuration.

From: Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator

Fig. 4

a Overall structure of the NTSR1–βArr1–SBI-553 complex 1. b The intracellular interface between NTSR1 and βArr1 in the NTSR1–βArr1–SBI-553 complex 1. c Detailed interactions at the major interface between the NTSR1 ICLs (ICL1 and ICL3) and βArr1. NTSR1 is shown in violet and βArr1 is shown in coral. d, e βArr1 structure derived from the NTSR1–βArr1–SBI-553 complex 1 illustrates the interactions between the phosphorylated C-tail and βArr1 (d). Interactions between the phosphorylated residues in NTSR1 C-tail and the positive charged residues in βArr1 and Fab30 are indicated (e).

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