Fig. 5: Interactions between NTSR1 and βArr1 in a core engagement configuration in the presence of SBI-553. | Cell Research

Fig. 5: Interactions between NTSR1 and βArr1 in a core engagement configuration in the presence of SBI-553.

From: Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator

Fig. 5

a Overall view of the core engagement configuration of NTSR1–βArr1–SBI-553 complex 3. b Superposition of NTSR1 from the complex 3, NTSR1–βArr1 complex (PDB: 6PWC) and the NTSR1–arrestin complex (PDB: 6UP7) shows that the finger loop of βArr1 is compatible with the location of SBI-553. c The intracellular interface between NTSR1 and βArr1 in the NTSR1–βArr1–SBI-553 complex 3. d Schematic illustration of the proposed working model of arrestin-biased agonism of NTSR1 potentiated by SBI-553.

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