Fig. 2: scRNAseq analysis of lung cells isolated from IAV-infected mice. | Cell Research

Fig. 2: scRNAseq analysis of lung cells isolated from IAV-infected mice.

From: Lung cell fates during influenza

Fig. 2

a–d Adult (8–12-week-old) C57BL/6 mice were infected intranasally with a 2500 EID50 dose of mouse-adapted influenza A/Puerto Rico/8/1934 virus, and lung cells isolated from infected mice were profiled by scRNAseq analysis. Violin plots of percent total cellular transcripts mapped to IAV genes in lung structural (a) and immune compartment (c) cell types, plotted on log scale, range 0–10% (dotted line represents estimated infection threshold). Proportion of cells infected within individual lung structural (b) and immune compartment (d) cell types based on estimated infection threshold. Data are from combined 3 and 6 dpi datasets. Cells were isolated from the lungs of 4–5 mice for each time point. The data have been published previously69 (NCBI BioProject PRJNA613670).

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