Table 1 Clinical trials of Urolithin A.

NCT02655393

Adults ≥ 61 and ≤ 85 years of age,

BMI ≥ 18 and ≤ 32 kg/m².

Safety, pharmacokinetic and pharmacodynamic assessment

Completed. UA is safe and bioavailable in humans. UA modulated muscle and mitochondrial biomarkers.³⁴¹

NCT04160312

Adults ≥ 18 and ≤ 80 years of age.

Bioavailability

Completed. Direct supplementation with UA significantly increased plasma levels of UA.³⁶¹

NCT06362018/NCT06853197

Adults ≥ 8 and ≤ 45 years of age,

BMI ≥ 18.5 and ≤ 30 kg/m².

Bioavailability

Completed. Results pending*.

NCT03464500

Adults ≥ 40 and ≤ 65 years of age,

BMI ≥ 25 and ≤ 34.9 kg/m².

Muscle function

Completed. Improved muscle strength, peak O₂ consumption, 6 min walk distance, reduced plasma inflammation marker.³⁴²

NCT03283462

Adults ≥ 65 and ≤ 90 years of age.

Muscle function

Completed. Improved muscle endurance measured by the number of muscle contractions until fatigue, reduced plasma inflammation marker.³⁷⁹

NCT04783207

Male adults ≥ 18 and ≤ 40 years of age, elite and sub-elite endurance runners.

Muscle function

Completed. Reduced rates of perceived exertion and indirect markers of post-exercise muscle damage, improved maximal O₂ consumption. Did not further enhance performance in highly trained endurance runners.³⁸⁰

NCT06556706

Frail adults ≥ 65 and ≤ 85 years of age,

BMI ≥ 18 and ≤ 35 kg/m².

Mitochondrial quality in muscle

Completed. Results pending*.

NCT05735886

Adults ≥ 45 and ≤ 70 years of age,

BMI ≤ 34.9 kg/m².

Mitochondrial activity in immune cells, immune function

Completed. UA elicits immune remodeling, characterized by changes in mitochondrial measurements and immune markers.³⁷⁷

NCT05921266

Obese adults ≥ 40 and ≤ 64 years of age,

BMI ≥ 30 kg/m².

Endothelial and cerebrovascular function

Completed.³⁸² Results pending*.

NCT06022822

Males ≥ 18, with confirmed prostate cancer undergoing radical prostatectomy.

Oxidative stress in tumor tissue

Recruiting*.

NCT06274749

Adults ≥ 55 and ≤ 64 years of age,

BMI ≥ 27 kg/m^2.

Insulin levels and glucose tolerance

Recruiting*.

NCT06324214

Adults > 40 years of age, with ≥ 10 pack-years of smoking history, with chronic obstructive pulmonary disease (COPD), during pulmonary rehabilitation.

Exercise endurance capacity

Recruiting*.

NCT07161310

Adults ≥ 18 years of age, with untreated solid cancer and planned Immune checkpoint inhibitor therapy.

Immune system

Not yet recruiting*.

NCT06990256

Adults ≥ 45 and ≤ 70 years of age, with Pittsburgh Sleep Quality Index > 5.

Sleep quality, aging markers

Not yet recruiting*.

NCT07060898

Adults ≥ 40 years of age.

Cognitive function

Active*.