Fig. 3
From: A critical epitope in CD147 facilitates memory CD4+ T-cell hyper-activation in rheumatoid arthritis
Effect of mAb 5A12 on activated Tm-mediated osteoclastogenesis. a, b Enhanced osteoclastogenesis by activated Tm cells in a co-culture system but not by activated Tn cells. The corresponding statistical results for TRAP+ cells are shown. c, d Effects of 5A12 on Tm-mediated osteoclastogenesis. 5A12 could significantly inhibit Tm-mediated osteoclastogenesis in the presence or absence of rhM-CSF and RANKL. The corresponding statistical results of TRAP+ cells are shown. *P < 0.05; **P < 0.01; ns, not significant
