Fig. 1

Schematic diagram of M6PR-mediated regulation of T cell fates. Strong mTORC1 expression induced by pro-inflammatory cytokine IL-2 causes enhanced transport of M6PR onto the cell surface, subsequently increasing the uptake of serine protease granzyme-B (Gzm-B) and resulting in T cell death (right). In contrast, weak mTORC1 as induced by IL-7 results in reduced transport of M6PR onto the cell surface, making T cells refractory to Gzm-B-mediated cell death (left). The role of other cytokines and costimulatory molecules in M6PR regulation is not known (?) and requires further studies. High cell surface M6PR on T cells may also result in T cell apoptosis via increased TGF-β activation or IGF2 degradation. However, no direct evidence is available. Red upright arrow () indicates an increase; red inverted arrow () indicates a decrease