Fig. 7
From: TCR–pMHC bond conformation controls TCR ligand discrimination
Mechanistic models of TCR triggering and discrimination. Correlations between TCR–pMHC bond conformation and calcium flux (a), TCR–CD3ζ distance (b), and CD3ζ phosphorylation (c). d Our proposed model for TCR ligand discrimination. The TCR–pMHC bond conformation controls the TCR–CD3ζ distance to regulate the exposure of ITAMs on CD3ζ for subsequent phosphorylation for the K5, MCC, and 102S pMHCs, respectively
