Table 1 2D kinetic parameters
From: TCR–pMHC bond conformation controls TCR ligand discrimination
Peptide | Sequence | T-cell activation | AcKa (µm4) | koff (s−1) | AcKon (µm4 s−1) |
|---|---|---|---|---|---|
K5 | ANERADLIAYFKAATKF | Super agonist | 3.7 ± 0.6 × 10−4 | 1.0 ± 0.3 | 3.6 ± 0.5 × 10−5 |
MCC | ANERADLIAYLKQATK | Agonist | 1.5 ± 0.7 × 10−4 | 1.3 ± 0.7 | 2.0 ± 1.1 × 10−5 |
102S | ANERADLIAYLKQASK | Weak agonist | 1.6 ± 0.7 × 10−5 | 1.5 ± 0.3 | 2.4 ± 0.8 × 10−6 |
