Fig. 4 | Cellular & Molecular Immunology

Fig. 4

From: The transcription factor Zfp281 sustains CD4+ T lymphocyte activation through directly repressing Ctla-4 transcription

Fig. 4

Zfp281 deficiency impairs the T-cell response to L. monocytogenes infection. a Flow cytometric analysis of antigen (LLO)-specific IFN-γ–producing CD4+ T cells in the spleens of WT and cKO mice sacrificed on day 7 after L. monocytogenes infection. The numbers adjacent to the outlined areas indicate the percentage of IFN-γ–producing CD4+ T cells (n = 5 for each group). b The frequency of CD4+ IFN-γ+ T cells as indicated in a. c Serum IFN-γ levels detected by ELISA. d L. monocytogenes titer in spleens and livers. CFU, colony-forming units. Data are representative of three independent experiments (mean ± s.d.). A two-tailed, unpaired t-test was used. NS not significant. *P < 0.05, ***P < 0.001

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