Fig. 4 | Cellular & Molecular Immunology

Fig. 4

From: A compromised specific humoral immune response against the SARS-CoV-2 receptor-binding domain is related to viral persistence and periodic shedding in the gastrointestinal tract

Fig. 4

Kinetics of viral RNA, anti-RBD antibodies, and neutralizing capacity. a Profiles of three representative negative retest COVID-19 patients with high levels of anti-RBD antibodies. Fifty-eight of 60 negative retest patients were in this group (see Supplementary Fig. 4). b Profiles of nine representative positive retest COVID-19 patients with low levels of anti-RBD antibodies. Seventeen of 19 positive retest patients were included in this group. c Profiles of one negative retest patient with low anti-RBD antibody titers and nonprotective neutralizing activity. Two of 60 negative retest patients were in this group. d Profiles of two positive retest patients with high levels of antibodies and neutralizing activity. Two of 19 positive retest patients were in this group. Black lines, IgM, IgA, and IgG; red line, viral load; green line, serum microneutralization. Patient ID numbers are shown on the top. Viral RNA below the detection limit was set at 1.44 log10. Folds of serum dilution were used as microneutralization titers

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