Table 2 Inhibitory activity of GPI-m36.4 on HIV-1 Env-mediated cell–cell fusion
From: Generation of HIV-resistant cells with a single-domain antibody: implications for HIV-1 gene therapy
HIV-1 Env | Subtype | Tropism | Mean % cell fusion ± SD | |
|---|---|---|---|---|
GPI-FluIgG03 | GPI-m36.4 | |||
398-F1_F6_20 | A | CCR5 | 108 ± 4 | 16 ± 5 |
92RW020 | A | CCR5 | 113 ± 2 | 0 |
92UG037.8 | A | CCR5 | 106 ± 4 | 0 |
NL4-3 | B | CXCR4 | 105 ± 4 | 0 |
SF162 | B | CCR5 | 105 ± 4 | 0 |
R3A | B | CCR5 | 98 ± 3 | 0 |
CNE11 | B' | R5X4 | 110 ± 10 | 0 |
ZM53M.PB12 | C | CCR5 | 108 ± 7 | 0 |
HIV_25710-2.43 | C | CCR5 | 108 ± 5 | 0 |
GX11.13 | A/E | CCR5 | 100 ± 6 | 5 ± 1 |
CNE8 | A/E | CCR5 | 107 ± 8 | 11 ± 3 |
CNE55 | A/E | CCR5 | 107 ± 10 | 10 ± 3 |
CH70.1 | B/C | R5X4 | 100 ± 2 | 0 |
CH119.10 | B/C | CCR5 | 106 ± 5 | 0 |
BJOX002000.03 | B/C | CCR5 | 110 ± 4 | 0 |
