Fig. 7 | Cellular & Molecular Immunology

Fig. 7

From: The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13

Fig. 7

OTUB1 deficiency decreases LPS-induced mortality by reducing cytokine production. a OTUB1fl/fl and CD11c-Cre OTUB1fl/fl mice were i.p. administered 10 mg/kg LPS. After 3 h, blood was collected, and cytokines in the sera were analyzed by ELISA (n = 9). b OTUB1fl/fl and CD11c-Cre OTUB1fl/fl mice were i.p. administered a low dose of LPS (10 mg/kg), and survival was monitored daily for 6 days (n = 10). Data are displayed as the mean ± SD. *p < 0.05 and **p < 0.01; n.s. not significant

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