Fig. 2
From: An update on the regulatory mechanisms of NLRP3 inflammasome activation
Posttranslational modifications (PTMs) in NLRP3 inflammasome components. The NLRP3 inflammasome is regulated by various PTMs, including ubiquitination/deubiquitination, phosphorylation/dephosphorylation, acetylation/deacetylation, SUMOylation, and nitrosylation, in different domains of NLRP3 (PYD, NACHT, and LRR). Activators and inhibitors of the NLRP3 inflammasome are represented by red and blue ovals, and phosphorylation sites of NLRP3 components from human and mouse species are indicated with (h) and (m), respectively.
