Table 2 Regulatory mechanisms by miRNA and lncRNA upon NLRP3 inflammasome activation
From: An update on the regulatory mechanisms of NLRP3 inflammasome activation
Regulator | NLRP3 regulation | Target | Study model | Associated disease/pathology | Ref. |
|---|---|---|---|---|---|
miR-223 | ↓ | 3ʹ-UTR of NLRP3 | BMDMs, BMDCs, Neutrophils | – | |
J744.2 macrophages, C57BL/6 mice | EAH and fibrotic NASH | ||||
RAECs, male SD rats | Atherosclerosis | ||||
miR-139 | ↓ | c-Jun | SH-SY5Y and BV2 cells | Cerebral I/R injury | |
miR-183 | ↓ | TXNIP | HEK293T and microglial cells, male SD rats | CCI-induced neuropathic pain | |
miR-421 | ↑ | FOXO3a | C2C12 cells, C57BL/6 mice | Ischemic muscle injury | |
miR-21 | ↑ | A20 | BMDMs, C57BL/6 mice | Septic shock | |
LncRNA ADAMTS9-AS2 | ↑ | miR-223-3p | CS-GC and CR-GC cell lines, GC tissues | Gastric cancer | |
LncRNA NEAT1 | ↑ | miR-3076-3p | BMDCs, BALB/c mice | Experimental autoimmune myocarditis |
