Fig. 1: Proposed scheme showing functional DC diversity. | Cellular & Molecular Immunology

Fig. 1: Proposed scheme showing functional DC diversity.

From: Dendritic cells in cancer immunology

Fig. 1

The genetic basis of functional DC diversity is shown with IRF8-dependent types, cDC1s and pDCs, shown on the left. Both cDC1s and pDCs function in antiviral immunity, with pDCs contributing type I interferon and cDC1 priming CD8 T cells through cross-presentation of antigens. cDC1s are also active in some intracellular infections, such as in Toxoplasma gondii, where their IL-12 production in response to pathogens is key for host defense. cDC1s also prime CD8 T cells to recognize tumor cell antigens through cross-presentation. cDC2s can aid in protection from other pathogens, and evidence suggests that defense against some pathogens, such as Citrobacter rodentium, relies on a Notch2-dependent program, while defense against helminths relies on KLF4 action in cDC2s.

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