Fig. 1
From: Regulation of antitumor immunity by inflammation-induced epigenetic alterations
Major epigenetic regulation in antitumor immunity. Histone posttranslational modifications and DNA methylation play crucial roles in adaptive immune responses, including dendritic cell development, antitumor cytokine silencing or expression, and T-cell priming and activation. However, such modifications also control the exhausted phenotype in tumor-infiltrating CD8+ T cells. In cancer cells, histone and DNA modifications affect tumor antigen production, antigen processing and presentation machinery components and PD-L1 induction. Chromatin remodeling also regulates the response to cytotoxic attack in cancer cells. Epigenetic modifying agents (EMAs) can enhance multiple aspects of the antitumor immune response
