Fig. 1: Immune responses in SARS-CoV-2-infected patients and vaccinated individuals. | Cellular & Molecular Immunology

Fig. 1: Immune responses in SARS-CoV-2-infected patients and vaccinated individuals.

From: T cell immune responses to SARS-CoV-2 and variants of concern (Alpha and Delta) in infected and vaccinated individuals

Fig. 1

A, B SARS-CoV-2 Spike-specific CD4+ and CD8+ T cells in healthy, infected and vaccinated individuals. Whole blood was stimulated with Spike peptides, and T cells with dual-cytokine staining were gated. The blue line shows the 0.05% cutoff. C The correlation of Nucleocapsid-specific IgG titers with CD4+ T cell immune responses to one or more of 5 major SARS-CoV-2 proteins in 25 patients. D The correlation between Spike-specific CD4+ T cell immune responses and Spike-specific IgG levels in 13 patients with elevated CD4+ Spike-specific T cell immune responses (IL-2+/TNF-α+ cell% in CD4+ >0.3%). E, F T cell immune responses to ancestral and variant spike peptides are shown. CD4+/CD8+ Spike-specific T cells from infected and vaccinated healthy individuals were assessed for reactivity to ancestral, Alpha variant and Delta variant Spike peptides. Each dot represents one individual. *P = NS; ***p < 0.001.

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