Fig. 8: KLF14 regulates glycolysis and the immune function of macrophages by inhibiting the transcription of HK2 and may play a role in sepsis. | Cellular & Molecular Immunology

Fig. 8: KLF14 regulates glycolysis and the immune function of macrophages by inhibiting the transcription of HK2 and may play a role in sepsis.

From: The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis

Fig. 8

Based on the previous findings, KLF14 is upregulated in sepsis and serves as an inflammation suppressor. KLF14 deletion promoted glycolysis in and inflammatory factor secretion by macrophages in sepsis. KLF14 regulated glycolysis in macrophages by inhibiting the transcription of HK2. Moreover, perhexiline activated the expression of KLF14 to reduce the immune response of macrophages upon LPS stimulation

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