Table 1 Thoracic radiograph observations and incidence in rhesus macaques infected with SARS-CoV-2 after one or two immunizations with unadjuvanted CoVLP, CoVLP+CpG, or CoVLP+AS03

From: Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates

 

Day 6

Day 13

Day 20

CoVLP

CoVLP+CpG

CoVLP+AS03

Control

CoVLP

CoVLP+CpG

CoVLP+AS03

Control

CoVLP

CoVLP+CpG

CoVLP+AS03

Control

Lungs

R

L

R

L

R

L

R

L

R

L

R

L

R

L

R

L

R

L

R

L

R

L

R

L

Animals challenged after one dose

 TBLN enlargement

0/6

0/6

1a/6

1a/6

0/6

0/6

0/4

0/4

0/3

0/3

0/3

0/3

0/3

0/3

0/2

0/2

0/3

0/3

0/3

0/3

0/3

0/3

0/2

0/2

 Increase in opacity

0/6

0/6

0/6

0/6

1/6

0/6

1/4

1/4

0/3

0/3

0/3

0/3

1/3

1/3

2/2

2/2

0/3

0/3

0/3

0/3

1/3

1/3

2/2

2/2

 Loss of definition

0/6

0/6

0/6

0/6

1/6

0/6

0/4

0/4

0/3

0/3

0/3

0/3

0/3

0/3

0/2

0/2

0/3

0/3

0/3

0/3

0/3

0/3

0/2

0/2

Animals challenged after two doses

 TBLN enlargement

1/6

1/6

0/6

1/6

0/6

0/6

0/4

1/4

0/3

0/3

0/3

0/3

0/4

0/4

0/2

0/2

0/3

0/3

0/3

0/3

1/4

1/4

0/2

0/2

 Increase in opacity

1/6

1/6

0/6

0/6

0/6

0/6

0/4

2/4

1/3

1/3

0/3

0/3

0/4

0/4

0/2

0/2

1/3

1/3

0/3

0/3

0/4

0/4

0/2

0/2

 Loss of definition

0/6

0/6

0/6

0/6

0/6

0/6

0/4

1/4

1/3

1/3

0/3

0/3

0/4

0/4

0/2

0/2

1/3

1/3

0/3

0/3

0/4

0/4

0/2

0/2

  1. Thoracic radiographs were obtained on Days 6, 13, and 20 post challenge for all animals, and tracheobronchial lymph node enlargement, increase in opacity, and loss of definition were evaluated in the right and left lungs.
  2. R right, L left, TBLN tracheobronchial lymph node
  3. Bold values indicate the occurence of radiographic findings
  4. aReported on the left and right lungs from different animals
Back to article page