Fig. 1
From: Ripping the Ripoptosome: a novel path for blocking allergic inflammation?
Activation of the RipIL-33 pathway drives the onset of type 2 innate responses. Brusilovsky and colleagues describe how various allergenic stimuli converge in the activation of the ripoptosome and how this contributes to the onset of type 2 innate responses. The authors provide evidence that allergen recognition by epithelial cells results in the activation of the RIPK-1/caspase 8 multiprotein complex called RipIL-33. Caspase 8 plays a key role in the RipIL-33 pathway. On the one hand, RIPK-1 is rapidly phosphorylated and subsequently degraded, thus attenuating death-inducing signals. On the other hand, caspase 8 promotes the maturation of IL-33 through targeted activation of caspase 3 and caspase 7 and corelease of histones. Figure created with BioRender.com
