Fig. 1
From: T cell epitopes in SARS-CoV-2 proteins are substantially conserved in the Omicron variant
T cell analysis against the Omicron variant. A Amino acid sequences of T cell epitopes identified from the original SARS-CoV-2 strain (NC_045512.2) were examined in the Omicron variant (EPI_ISL_6699770, GISAID). Four different sets of previously identified T cell epitopes were used for comparisons. Percentages of completely conserved epitopes are presented as bar graphs. B, C IFN-γ intracellular staining was performed using PBMCs from COVID-19 convalescents (N = 7; 45–125 days after symptom onset) and BNT162b2-vaccinated individuals (N = 12; 3 months after the second vaccination). PBMCs were stimulated with OLP pools to spike the original strain and Omicron. The ratio of the frequency of IFN-γ+ cells after stimulation with the Omicron spike OLPs to the frequency after stimulation with the original spike OLPs is presented as a percentage. Statistical analysis was performed using paired t tests. *p < 0.05; ns not significant
