Fig. 4
From: Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2
Cross-neutralizing antibodies induced by different mutants against different VOCs. A Comparison of the fold changes of neutralizing IC50 relative to D614G elicited by 19 groups of DNA immunogens (y-axis) against different VOCs, including the wild type, D614G, B.1.1.7, B.1.351, P1, B.1.617.2 and B.1.1.529 (x-axis). B Typical percent inhibition of D614G-, B.1.1.7-, B.1.351-, Del 69–70-, S982A-, and L18F-immunized sera against major VOCs, including the wild-type (Wuhan-Hu-1), D614G, B.1.1.7, B.1.351, P1, B.1.617.2 and B.1.1.529. Data were analyzed for statistical significance using the unpaired Student’s t test between the reference (D614G) group and other groups against each VOC. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001
