Fig. 6
From: Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2
T-cell response to a single spike mutation of B.1.1.529. The frequencies of spike-specific IFN-γ+CD4+ T cells (A, B) and IFN-γ+CD8+ T cells (C, D) elicited by 14 groups of DNA immunogens covering the RBD domain of B.1.1.529 mutants after stimulation with the full wild-type spike peptide pool (Wuhan Hu-1) and the B.1.1.529 spike peptide pool. Data were analyzed for statistical significance using the unpaired Student’s t test. Data are shown as the mean with SD in each group. Dotted black lines indicate the limit of quantification (LOQ) in (A–D)
