Fig. 3 | Cellular & Molecular Immunology

Fig. 3

From: A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19

Fig. 3

Monocytes enhance the cytokine release of SARS-CoV-2-S CAR-T cells. A THP1, S-293T, and SARS-CoV-2-S CAR-T cells were mixed at the indicated ratios for three days before measuring the secretion of IFNγ and IL6 (mean ± s.e.m, ***P < 0.001). Data presented are the mean (± s.e.m) from three repeats. B Cells as described in A were subjected to measurement of the secretion of multiple cytokines by a multiplex bead array (mean ± s.e.m). C The violin plot shows the expression of IL8 (CXCL8) in the PBMCs of COVID-19 patients and healthy controls (***P < 0.001)

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