Fig. 6 | Cellular & Molecular Immunology

Fig. 6

From: A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19

Fig. 6

A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as effective treatments for SARS-CoV-2-infected Syrian hamsters. We demonstrated the feasibility of producing SARS-CoV-2-S CAR-T cells that have immunological profiles similar to those of T cells from COVID-19 patients in the presence of the S protein. This CAR-T-cell model can be used to screen drugs to suppress SARS-CoV-2-induced cytokine release. Among the drugs screened, felodipine, fasudil, imatinib, and caspofungin are effective in protecting against SARS-CoV-2-induced lethal inflammation in Syrian hamsters

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