Fig. 3: Systemic IgG subtype kinetics following vaccination.
From: B-cell and antibody responses to SARS-CoV-2: infection, vaccination, and hybrid immunity
S-specific humoral responses induced by the basic immunization cycle with mRNA vaccines are dominated by IgG1 and IgG3, which possess proinflammatory Fc functionalities. Late after the second vaccination, and especially after the booster dose, IgG1 is still dominant, but the fraction of noninflammatory IgG3 and IgG4 is substantially increased. Antibody kinetics and relative levels are simplified for ease of interpretation. Created with BioRender.com
