Fig. 2
From: In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Graphic summary of next-generation approaches for broadly targeted and pan-coronavirus vaccines, including nanoparticle delivery; the use of mosaic antigens or serial vaccination to educate the immune system with multiple versions of a given viral protein; the use of novel regions of the virus, in particular conserved regions outside of spike; and finally, consensus sequence design or computational antigen design, to select the antigenic sequence that induces the most broadly reactive immunity. NP nucleoprotein, NSP non-structural protein, ORF open reading frame, RBD receptor binding domain, RTC replication-transcription complex. Created with BioRender.com
