Table 2 Comparison of CAR- and TCR-engineered NK cells
From: Development of NK cell-based cancer immunotherapies through receptor engineering
CAR | TCR | |
|---|---|---|
HLA restricted | No | Yes |
Antigen density required | High | Low |
Intracellular targeting | No | Yes |
Multiplexing | Yes | Yes |
Off the shelf | Yes | Yes |
Clinical test | Yes | No |
