Fig. 4
From: Bridging the gap with multispecific immune cell engagers in cancer and infectious diseases
Overview of NK-cell engagers (NKCEs) in cancer. NKCEs are generally composed of single-chain variable fragments (scFvs) or specific ligands directed against i) NK cell targets such as CD16a (purple), IL-15R (blue and purple), NKp46 (green), NKp30 (yellow), NKG2C (pink) or CD122 (dark blue), and ii) tumor-associated antigens such as CD33 (red), CD30 (green), EpCAM (yellow and orange), CD133 (dark blue), EGFR (light green), BCMA (pink), HER2 (light purple) or CD123 (light yellow). BiKE bispecific killer engager, TriKE trispecific killer engager, TetraKE tetraspecific killer engager, EGFR epidermal growth factor receptor, BCMA B-cell maturation antigen, HER2 receptor protein tyrosine kinase erbB-2, TEM8 tumor endothelial marker 8, CLEC12 C-type lectin domain family 12 member A, IL-15R IL-15 receptor, IL-2v IL-2 variant. Created with Biorender
