Fig. 1 | Cellular & Molecular Immunology

Fig. 1

From: Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells 

Fig. 1

Three-step developmental model of IL-23-producing cDCs. The activation of Notch2 signaling serves as the initial trigger for the differentiation process of EpCAM+ DCIR+ cDCs. This is followed by the induction of CIA-DC signature genes, such as LyzM, in cDCs through lymphotoxins from ILC3s and their recruitment into tertiary lymphoid organs. Ultimately, the terminal differentiation of these cells necessitates the involvement of retinoic acid signaling, which is pivotal for endowing them with robust ability to produce IL-23

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