Table 1 The roles of IL-22 in colitis models

Article	Colitis model	Method	The role of IL-22	The role of IL-23	Ref
Sugimoto et al.	DSS	anti-IL-22 Ab	Protective		[45]
Moniruzzaman et al.	DSS	Il22ra^−/−	Protective		[46]
Bishop et al.	DSS	anti-IL-22 Ab	Protective		[47]
Zenewicz et al.	DSS	Il22^−/−	Protective		[48]
	naïve T Transfer	Il22^−/− T cells into Il22^−/− Rag2^−/−	Protective
	naïve T Transfer	Il22^−/− T cells into Rag2^−/−	Not significant
Gunasekera et all	Il10 KO	Il22^−/−	Inflammatory		[49]
Bernshtein et al.	Cx3cr1^Cre Il10ra^flox/flox	Il22^−/−	Inflammatory	Inflammatory	[50]
Morrison et al.	Hh + anti-IL-10	anti-IL-22 Ab	Inflammatory		[51]
Wang et al.	Hh infection in 129Rag2^−/−	anti-IL-22 Ab	Inflammatory		[52]
Reyes et al.	TNBS	Il22^−/−	Inflammatory		[53]
Eken et al.	CD40 agonistic antibody	anti-IL-22 Ab	Inflammatory	Inflammatory	[54]
Pearson et al.	CD40 agonistic antibody	anti-IL-22 Ab	Not significant		[55]
Pavlidis et al.	Tbx21^−/− Rag2^−/− (TRUC)	Il22^−/−	Inflammatory		[56]

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