Table 2 The roles of IL-17 in colitis models

Article	Colitis model	Method	The role of IL-17	The role of IL-23	Ref
Ogawa et al.	DSS	anti-IL-17A Ab	Protective		[63]
Lee et al.	DSS	Il17a^−/−	Protective	Inflammatory	[64]
Yang et al.	DSS	Il17a^−/−	Protective		[65]
Yang et al.	DSS	Il17f^−/−	Inflammatory		[65]
Ito et al.	DSS	Il17a^−/−	Inflammatory		[72]
Maxwell et al.	Abcb1^−/−+ H.billis	anti-IL-17A Ab	Protective	Inflammatory	[66]
	Abcb1^−/− + H.billis	anti-IL-17F Ab	Not significant	Inflammatory
	Abcb1^−/− + H.billis	anti-IL-17RA Ab	Protective	Inflammatory
Tachibana et al.	Il10^−/−	Il17a^−/−	Protective		[67]
Morrison et al.	Hh + anti-IL-10	anti-IL-17A Ab	Protective (only in cecum)		[51]
O’Connor et al.	naïve T transfer	Il17a^−/− T cells	Protective		[68]
Schmidt et al.	naïve T transfer	anti-IL-17A Ab	Inflammatory		[69]
		anti-IL-17F Ab	Not significant
		anti-IL-17A/F Ab	Inflammatory
Leppkes et al.	naïve T trasfer	Il17a^−/− T cells	Not significant		[70]
		Il17f^−/− T cells	Not significant
		Il17f^−/− T cells + anti-IL-17A Ab	Inflammatory
Zhang et al.	TNBS	Il17ra^−/−	Inflammatory		[71]
Eken et al.	CD40 agonistic antibody	anti-IL-17RA Ab	Not significant	Inflammatory	[54]
Pearson et al.	CD40 agonistic antibody	anti-IL-17A Ab	Not significant		[55]

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