Table 3 The roles of GM-CSF in colitis models

From: Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cellsĀ 

Article

Colitis model

Method

The role of GM-CSF

The role of IL-23

Ref

Pearson et al.

CD40 agonistic antibody

Anti-GM-CSF Ab

Inflammatory

Inflammatory

[55]

Griseri et al.

NaĆÆve T transfer

Anti-GM-CSF Ab

Inflammatory

Inflammatory

[76]

Griseri et al.

Hh + anti-IL-10R

Csf2rbāˆ’/āˆ’ or

anti-GM-CSF Ab

Inflammatory

Inflammatory

[77]

Han et al.

NSAID-induced ileitis

Csf2āˆ’/āˆ’, Csf2rbāˆ’/āˆ’or

Anti-GM-CSF Ab

Protective

Ā 

[81]

Sainathan et al.

DSS

Inject recombinant mouse GM-CSF

Protective

Ā 

[78]

Xu et al.

DSS

Csf2āˆ’/āˆ’

Protective

Ā 

[79]

Egea et al.

DSS

Csf2āˆ’/āˆ’

Protective

Ā 

[80]