Fig. 2
From: Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway
Loss of Nudt21 in Macrophages Alleviates Excessive Inflammation in an HLH Model. A Survival curves of WT and Nudt21-cKO mice in the hemophagocytic lymphohistiocytosis (HLH) model, with polyI:C (10 mg/kg) followed by lipopolysaccharide (LPS) (5 mg/kg) injections (n = 5 per group). Survival curves were analyzed via the log-rank (Mantel‒Cox) test. Analyses conducted 6 hours post-LPS injection included rectal temperature changes (B), body weight changes (C), white blood cell counts in peripheral blood (D), representative H&E-stained spleen sections and spleen injury scores (E) (n = 3 per group), the ratio of spleen weight to body weight (F), and the mRNA expression levels of Il6 and Il1β in spleen tissues (G). P values were determined by unpaired Student’s t test. (H) Survival curves of WT and Nudt21-cKO mice following the indicated treatments (n = 6 per group). Survival curves were analyzed via the log-rank (Mantel‒Cox) test. The error bars represent the standard errors of the means (SEMs)
