Fig. 6
Pim2 is a therapeutic target for inflammatory arthritis. A Schematic of CIA model mice treated with HJ-PI01 (10 or 20 mg/kg). B CIA scores and hind paw thickness of the mice in each group (n = 6). C Macroscopic images, micro-CT, H&E, and safranin O staining of the ankles from the mice in each group (n = 6). D The expression of TNF-α, IL-1β, IL-6 and IL-10 in the mice in each group, as detected by IHC (n = 6). E The expression of iNOS and Arg-1 in the synovial macrophages of the mice in each group, as detected by immunofluorescence staining (F4/80, green; iNOS, red; Arg-1, red) (n = 6)
