Fig. 6 | Cellular & Molecular Immunology

Fig. 6

From: γδ+ T-cell-derived IL-17A stimulates airway epithelial/stromal cells to secrete G-CSF, promoting lung-specific pathogenic Siglec-F+ neutrophil development in PPE-induced emphysema

Fig. 6

RNA bulk-seq analysis of G-CSF-stimulated neutrophils versus control neutrophils. A Volcano plot of differential gene expression between G-CSF-stimulated (6 h) BM-neutrophils (G-CSF neutrophils) and medium-cultured control BM-neutrophils (med neutrophils). B Gene set enrichment analysis (GSEA) of gene sets associated with inflammatory responses in G-CSF-stimulated BM-neutrophils compared with control BM-neutrophils cultured in medium. C Heatmap of inflammatory response-related genes from RNA bulk-seq analysis of G-CSF-stimulated BM-neutrophils compared with control BM-neutrophils. D GSEA of gene sets associated with hallmark IL6-JAK-STAT3 signaling (left), hallmark PI3K-AKT-mTOR signaling (middle), and the BIOCARTA p38 MAPK pathway (right) in G-CSF-stimulated BM-neutrophils compared with control BM-neutrophils. E Heatmap of STAT3 target genes, mTOR target genes, and p38 target genes from RNA bulk-seq analysis of G-CSF-stimulated BM-neutrophils compared with control BM-neutrophils

Back to article page