Fig. 9: Simulation of the NPs applied as drug delivery carriers based on nano-bio interfaces. | NPG Asia Materials

Fig. 9: Simulation of the NPs applied as drug delivery carriers based on nano-bio interfaces.

From: Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application

Fig. 9

a Uptake kinetics of cationic particles with ionic imbalance transmembrane potential. Reproduced with permission53. Copyright 2013, American Chemical Society. b Schematic representation of the simulation model for magnetic NPs. c Phase diagram of membrane rupture by a rotational spherical NP as a function of binding strength and rotational speed when the NP is attached to or endocytosed by the membrane. The symbol ✩ represents a case with cell rupture, and ○ represents a case resulting in an intact cell membrane. Reproduced with permission56. Copyright 2017, American Chemical Society. d Cryo-transmission electron microscopy (TEM) images of lipid vesicles in the presence of GO. e Cartoon illustrating the superstructure integrating GO inside the cell membrane. f The area ratio between pores and GO and the diffusion exponent, α, as a function of Ka. g The initial and final simulation configurations of the drug beads undergoing intramembrane delivery from sandwiched GO. h The initial and final configurations of the drug beads undergoing intracellular delivery. Reproduced with permission57. Copyright 2019, American Association for the Advancement of Science.

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