Fig. 6: MS@G5-AHP/miR-140 reduces articular space width narrowing and osteophyte formation in mice withosteb oarthritis.
From: Injectable “nano-micron” combined gene-hydrogel microspheres for local treatment of osteoarthritis

a Representative X-ray radiographs of the mouse knee joints showing the intra-articular injection of PBS, MS@G5-AHP/miR-NC, G5-AHP/miR-140, and MS@G5-AHP/miR-140 in the treatment of DMM-induced osteoarthritis at 1 and 12 weeks after surgery. b, c The relative articular space width between the medial compartments of mouse knee joints at 1 week and 12 weeks after surgery. n = 3. *P < 0.05. d The reconstructed micro-CT results revealed osteophyte formation to evaluate the therapeutic effect of MS@G5-AHP/miR-140 on OA at 12 weeks post surgery.