Fig. 7: MS@G5-AHP/miR-140 reduces cartilage degeneration in mice with osteoarthritis.
From: Injectable “nano-micron” combined gene-hydrogel microspheres for local treatment of osteoarthritis
a–c Representative H&E staining, toluidine blue staining, and safranin Ofast green staining of the cartilage sections after treatment of osteoarthritis using PBS, MS@G5-AHP/miR-NC, G5-AHP/miR-140, and MS@G5-AHP/miR-140 at 12 weeks after surgery. The MS@G5-AHP/miR-140 group presented the best result in maintaining the columnar architecture of normal cartilage. d Glycosaminoglycan (GAG) content relative to that in the sham group obtained from the quantification of toluidine blue staining and safranin Ofast green staining of the cartilage sections using ImageJ software. The values are presented as the mean ± SD, n = 10. **P < 0.01, ****P < 0.0001. e OARSI score of articular cartilage for each group after treatment for 12 weeks. The values are presented as the mean ± SD, n = 10. *P < 0.05, **P < 0.01, compared with the PBS group. f Depth of cartilage lesions for each group after treatment for 12 weeks. The values are presented as the mean ± SD, n = 10. ****P < 0.0001, compared with the PBS group.
