Fig. 10: Hybrid nanopores for single-molecule sensing.
From: Hierarchically engineered nanochannel systems with pore-in/on-pore structures
Schematic of single biological (a) and solid-state nanopore (b) sensing, and the resultant current trace (c) that corresponds to the molecular characteristic at the single molecule level. d Schematic representation of the DNA origami structure with a nanopore. e The formation of a hybrid nanopore under the applied voltage. f Typical λ-DNA events through the hybrid nanopore. Reproduced with permission93. Copyright 2012, American Chemical Society. g Schematic illustrating the α-HL mutant nanopore modified with β-CD in the lipid bilayer and the corresponding molecular model. h, i Schematic of the detection of AMP, ADP, and ATP (h) and the resultant representative ionic current traces and static histograms (i). j Representative current traces of the ionic current when monitoring the ATP hydrolysis process. Reproduced with permission. Reproduced with permission95. Copyright 2019, American Chemical Society.
