Fig. 4: Antitumor effect and tissue toxicity of Pt NCs against osteosarcoma in vivo. | NPG Asia Materials

Fig. 4: Antitumor effect and tissue toxicity of Pt NCs against osteosarcoma in vivo.

From: Novel platinum nanoclusters (Pt NCs) induce mitochondrial apoptosis and damaging autophagy for the treatment of osteosarcoma—from the perspective of P53 mutation status in different cell lines

Fig. 4

A Macroscopic photos of nude mice and tumor bodies of xenograft tumor transplantation models of specific concentrations of PBS (blank control group), cisplatin (control group), and Pt NCs group (experimental group). B The macroscopic photographs and HE staining results of the heart, liver, spleen, lung, and kidney of the xenograft model represented the tissue toxicity of the drug. C Tumor body weight changes in xenograft model. D Body weight changes of nude mice in xenograft model.

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