Fig. 5: Effects of Pt NCs on cell cycle, DNA damage, and mitochondrial membrane potential in MG-63 (P53−). | NPG Asia Materials

Fig. 5: Effects of Pt NCs on cell cycle, DNA damage, and mitochondrial membrane potential in MG-63 (P53−).

From: Novel platinum nanoclusters (Pt NCs) induce mitochondrial apoptosis and damaging autophagy for the treatment of osteosarcoma—from the perspective of P53 mutation status in different cell lines

Fig. 5

A The detection of the cell cycle showed that the percentage of cells in the G1 phase increased, suggesting that the cells were arrested in the G1 phase. B Western blot of γH2A.X, representing DNA damage. C Detection of mitochondrial membrane potential, representing mitochondrial apoptosis. Green fluorescence represents a lower mitochondrial membrane potential, and its percentage reduction represents a decrease in mitochondrial membrane potential, indicating early mitochondrial apoptosis.

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