Abstract
Polymer field-effect transistors (PFETs) are among the most fascinating electronic devices because of their attractive properties, such as durability, environmental friendliness, and solution processability. To date, PFETs have been employed for the development of flexible displays, radio-frequency identification tags, flexible non-volatile memories, among others. Moreover, due to the above advantages, PFETs can be applied to disposable on-site analytical devices. In that regard, we have developed extended-gate type PFETs with molecular recognition biomaterials for protein sensing in aqueous media. The fabricated PFETs were used to successfully detect glycoproteins (immunoglobulin A, immunoglobulin G, and chromogranin A) without any complicated labeling processes. Since our proposed immunoassay, which is performed on the basis of extended-gate type PFETs, is rapid and easy-to-use, PFET will be an attractive platform for on-site monitoring devices in healthcare applications in the near future.
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Acknowledgements
We gratefully acknowledge financial support from the Towa Foundation for Food Science and Research, the Kanamori Foundation, the Descente and Ishimoto Memorial Foundation for the Promotion of Sports Science, Tateishi Science and Technology Foundation, Society for Research on Umami Taste, and Japan Society for the Promotion of Science (JSPS, Grant-in-Aid for Scientific Research, Nos. 16J08092, 17H04882, 17K14489, and 18J21190). We also thank Prof. S. Tokito (Yamagata University), Prof. O. Niwa (Saitama Institute of Technology), Dr. R. Kurita and Dr. S. Wakida (National Institute of Advanced Industrial Science and Technology) for their technical support and valuable feedback. YS is also grateful to the JSPS Research Fellowships for Young Scientists.
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Minamiki, T., Sasaki, Y., Su, S. et al. Development of polymer field-effect transistor-based immunoassays. Polym J 51, 1–9 (2019). https://doi.org/10.1038/s41428-018-0112-0
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DOI: https://doi.org/10.1038/s41428-018-0112-0
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