Fig. 7 | The Journal of Antibiotics

Fig. 7

From: Recombinant yeast and human cells as screening tools to search for antibacterial agents targeting the transcription termination factor Rho

Fig. 7

Possible implication of a lower affinity of the ATP pocket in the moderate growth defect induced by Rho from P. aeruginosa. a Multiple sequence alignment showing the mutation Met-186-Ile within the ATP pocket of Rho from P. aeruginosa as compared to that of E. coli and other bacterial strains. b Rho protomer crystal structure PDB 1XPU [26] showing the ATP pocket where the adenine moiety of ATP is stacked between the side chains of the two conserved amino acid residues Met186 and Phe355

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