Abstract
Three new bisabolane sesquiterpenoid esters, aspertenols A–B (1–3), and six known compounds (4–9) were isolated from the fungus Aspergillus tennesseensis. The structures of new compounds were elucidated by extensive spectroscopic analysis. The cytotoxicities of 1–9 against A549, K562, and ASPC cell lines were tested by using the CCK8 method. Compounds 1, 3, 4, 6, 7, and 9 showed inhibition on K562 cell line with IC50 values in the range from 16.6 to 72.7 μM. Compounds 1, 4, and 9 showed moderate inhibitory activity against A549 with IC50 of 43.5, 70.2, and 61.1 μM, respectively.
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This work was supported in part by the National Natural Science Foundation of China (81673334).
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Liu, L., Liu, R., Basnet, B.B. et al. New phenolic bisabolane sesquiterpenoid derivatives with cytotoxicity from Aspergillus tennesseensis. J Antibiot 71, 538–542 (2018). https://doi.org/10.1038/s41429-018-0025-3
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DOI: https://doi.org/10.1038/s41429-018-0025-3
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